This year Elucidata is presenting 6 posters ranging from Artificial Intelligence (AI) in omics, Data Lakes, Integrated metabolomic workflows, Fluxomics, PeakML and more in partnership with Agios Pharmaceuticals, Bruker, Yale University, NIH/NCATS, University of Louisville, SCIEX, and others. You can view the posters on the official link for ASMS using the poster codes.
With the advancement in high-throughput technologies, it is now possible
to perform large-scale metabolomics studies. Key challenges remain
in removing inherent noise, peak detection and manually evaluating
the global profile of metabolites from multiple biological samples,
which requires considerable time and expertise.
Richa Mudgal; Kailash Yadav; Sailful Bari Khan; Shashank Jatav; Kelly Marsh; Brian Dranka; Abhishek Jha
Three Thiazolidinediones analogs (troglitazone, rosiglitazone and pioglitazone)
were used to study PPAR-Gamma biochemistry in HepaRG cells using a
combined metabolomic-transcriptomic approach. HepaRG is a stem cell
derived cell model that is biochemically similar to human primary hepatocytes.
John Janiszewski; Matt Hall; Sam Michael; Richard Schneider; Stephen Ferguson; Michael Iannotti; Rebecca Cardone; Richard G.. Kibbey; Raghav Sehgal; Qiushi Sun; Surbhi Poddar; Maheswari Karthikeyan; Sunil Dhakad; Darren Dumlao; Elias Padilha; Kelli Wilson
LC-MS has long been employed to profile metabolic pathways of endogenous
metabolites. By combining LC elution, accurate MS, and MS/MS fragmentation,
a degree of structural information is accumulated with high confidence
toward unequivocal identification.
Richard Schneider; John Janiszewski; Sam Michael; Matt Hall; Stephen Ferguson; Michael Iannotti; Surbhi Poddar; Maheswari Karthikeyan; Sunil Dhakad; Raghav Sehgal; Rebecca Cardone; Qiushi Sun; Richard G. Kibbey ...........................................................
With the advent of high throughput Omic approaches to analyze biological
samples, terabytes of genomics, metabolomics, transcriptomics, proteomics,
phenomics and other Omic datasets are routinely generated.
Raghav Sehgal; Qiushi Sun; Rebecca Cardone; Richard Martyn Williams; Xiaojian Zhao; Surbhi Poddar; Richa Mudgal; Richard Schneider; Richard G. Kibbey
The mechanism of action of ~20% of FDA approved drugs is unknown. For
many more off-target effects remain poorly described. Compounds orphaned
for one indication might have an on or off-target effect that benefit
another indication in mono- or combination therapy.
Raghav Sehgal; Rebecca Cardone; Richard Martyn Williams; Xiaojian Zhao; Qiushi Sun; Surbhi Poddar; Richa Mudgal; Richard Schneider; Richard G. Kibbey
LC-MS based fluxomics studies provide researchers the ability to detect
and quantify incorporation of isotopically labeled atoms into an organism’s
metabolites. Ion mobility separation adds a further dimension for detection
and annotation of metabolites.
Heino M. Heyman; Heiko Neuweger; Pawel Konrad Lorkiewicz; Bradford G. Hill; Kyle Fulghum; Shefali Lathwal; Avijit Zutshi; Brian Dranka; Swetabh Pathak; Abhishek Jha
Elucidata presented 5 posters at ASMS 2019. These posters covered the A to Z in mass spectrometry. Ranging from quantification, to flux analyses, to complete metabolomic analyses, our posters showcased ways to do them more efficiently and a lot more faster. View our posters to learn more.
Shefali Lathwal, Shubhra Agrawal, Raghav Sehgal, Surbhi Poddar, Rishabh Gupta, Saiful Khan, Sahil Kumar, Sabu George, Swetabh Pathak, Abhishek JhaView Poster
Abhishek Jha, Avijit Zutishi, Raghav Sehgal, Shubham Agarwal, Taranjyot Singh, Shefali Lathwal, Swetabh Pathak, Alex Muir, Caroline Lewis, Mark Sullivan, Matthew G. Vander HeidenView Poster
Swetabh Pathak, Raghav Sehgal, Surbhi Poddar, Shubham Agarwal, Taranjyot Singh, Shefali Lathwal, Abhishek Jha, Shawn M. DavidsonView Poster
Khatereh Motamedchaboki, Robert Proos, Sara Ahadi, Raghav Seghal, Hemen Boro, Abhishek Jha, Latha PalaniappanView Poster
David Heywood, Suraj Dhungana, Johannes PC Vissers, Abhishek Jha, Raghav Sehgal, Amrita Cheema, Maria Laura AvantaggiatiView Poster
Download and view the posters presented by Elucidata at ASMS 2018.
Rewired Metabolism of T-cells upon mTORInhibition: Development of an Integrated Omics Pipeline
Darren Dumlao, Samantha Hiemer, Mary Piotrowski, Shashank Jatav, ShefaliLathwal, Raghav Sehgal, Abhishek Jha, John Janiszewski, Hozefa Bandukwala
Evaluation of Novel Software Tools for Automating Metabolomic Flux, Kinetics and Pathway Mapping
Baljit Ubhi, Loren Olson, Deepak Sharma, Kanika Sori, Raghav Seghal, Abhishek Jha
Automating qualitative and quantitative flux pipelines
Shefali Lathwal, Sunil Dhakad, Tiago C. Alves, Abhishek Jha, Richard G. Kibbey
PollyTM: A novel cloud-based platform for Metabolism labs
Abhishek Jha, Swetabh Pathak, Sabu George, Raghav Sehgal, Shefali Lathwal, Darren Dumlao, Mary Piotrowski, John Janiszewski